Symptom-Specific Assessment
📥 Symptom Specific Assessment
Mehay's A-Z Symptom-Specific Question Guide
Mehay's comprehensive guide · 60 common GP presentations · Questions grouped by clinical system · Tap to expand
Abdominal Pain ▼
- Location (RUQ, LUQ, epigastric, periumbilical, RIF, LIF, suprapubic, generalised)
- Onset (sudden vs gradual)
- Character (colicky, constant, sharp, dull, burning, cramping)
- Radiation
- Severity (0–10)
- Duration
- Timing (constant, intermittent, postprandial)
- Nausea / vomiting
- Haematemesis / coffee-ground vomit
- Bowel habit change
- Rectal bleeding / melaena
- Appetite loss
- Weight loss
- Jaundice
- Heartburn / acid reflux
- Bloating / distension
- Last bowel motion
- Food intolerance
- Dysuria
- Frequency / urgency
- Haematuria
- Loin pain / flank radiation
- LMP
- Risk of pregnancy / ectopic (PV bleeding, shoulder tip pain)
- Vaginal bleeding / discharge
- Dyspareunia
- Contraception
- Radiation to back (aortic aneurysm)
- Pulsatile abdominal sensation
- Risk: male, >65, smoker, vascular disease
- Fever
- Weight loss
- Night sweats
- Travel history
- Medication (NSAIDs, steroids, antibiotics)
Ankle Pain / Inversion Injury ▼
- Mechanism (inversion, direct trauma, twisting)
- Onset (immediate vs delayed swelling)
- Weight-bearing ability (key: can walk 4 steps?)
- Swelling location (lateral vs medial vs anterior)
- Bruising
- Locking / giving way
- Previous ankle injuries
- Tenderness at posterior 6cm or tip of lateral malleolus
- Tenderness at posterior 6cm or tip of medial malleolus
- Inability to weight bear 4 steps immediately AND in clinic
- — Absence of all three = fracture excluded (near 100% sensitivity)
- Tenderness at navicular bone
- Tenderness at base of 5th metatarsal (avulsion fracture — very common inversion injury)
- Unable to weight bear 4 steps
- ATFL tear (most common): anterior lateral tenderness, anterior drawer positive
- Peroneal tendon injury: posterior to lateral malleolus
- 5th metatarsal base avulsion: point tenderness, Ottawa foot rules positive
- High ankle sprain (AITFL): above malleolus, syndesmosis tenderness, longer recovery
- Osteochondral talus lesion: deep ankle pain, catching, may be missed on X-ray
- Maisonneuve fracture: proximal fibula fracture — feel entire fibula on all ankle injuries
- Achilles tendon rupture: pop, plantarflexion weakness, positive Thompson test
- Previous sprains / ankle instability
- Hypermobility (Ehlers-Danlos)
- Peripheral neuropathy (painless Charcot ankle in diabetics)
- Gout / pseudogout (crystal arthropathy in ankle)
Ankle Swelling / Oedema ▼
- Orthopnoea (number of pillows)
- Paroxysmal nocturnal dyspnoea
- Breathlessness on exertion
- Exercise tolerance
- Palpitations
- Chest pain
- Previous cardiac history
- Frothy urine (proteinuria)
- Reduced urine output
- Haematuria
- Periorbital puffiness
- Jaundice
- Alcohol history (units/week)
- Abdominal distension (ascites)
- Easy bruising
- Unilateral vs bilateral (unilateral = DVT until proven otherwise)
- Varicose veins
- Previous DVT
- Recent immobility / long-haul travel
- Leg pain / tenderness
- Cold intolerance
- Weight gain
- Constipation
- Dry skin / hair (hypothyroidism)
- Calcium channel blockers (amlodipine)
- Steroids
- NSAIDs
- Gabapentinoids (pregabalin, gabapentin)
- Nutritional status / malnutrition
- Pregnancy
- BMI
Back Pain — Low ▼
- Onset (sudden vs gradual)
- Character (aching, sharp, shooting)
- Radiation (buttock, leg — dermatomal)
- Aggravating factors (movement, sitting, standing, coughing)
- Relieving factors (rest, analgesia)
- Previous episodes
- Occupational / lifting history
- Saddle / perineal anaesthesia (NEW)
- Urinary retention or incontinence (NEW)
- Bowel dysfunction / faecal incontinence (NEW)
- Bilateral leg weakness or numbness
- Sexual dysfunction (new onset)
- ANY of the above = same-day emergency MRI and surgical review
- Age < 45 at onset
- Morning stiffness > 1 hour
- Improves with exercise, worse with rest
- Night pain (wakes in second half of night)
- Sacroiliac / buttock pain (alternating or bilateral)
- Family history: AS, psoriasis, IBD, uveitis
- Check HLA-B27, MRI sacroiliac joints
- Bilateral leg pain, heaviness, numbness, weakness on walking
- Relieved by bending forward (shopping trolley), sitting, or squatting — lumbar flexion opens spinal canal
- Worse with standing and walking (contrast: vascular claudication = relieved by standing still)
- Age usually > 60
- Insidious, progressive
- MRI lumbar spine for diagnosis
- Age > 50
- Unremitting / progressive pain
- Thoracic spine involvement
- Unexplained weight loss
- Night pain (wakes from sleep)
- Previous or current malignancy
- Systemically unwell
- Raised inflammatory markers + bone pain = investigate
- Known primary: breast, prostate, lung, kidney, thyroid (BPLTK) = most common to metastasise to spine
- Fever / night sweats
- Recent UTI / dental / surgical procedure (pyogenic discitis)
- IV drug use (staphylococcal discitis)
- Pott's disease (TB spondylitis): insidious onset, thoracic spine most common, gibbus deformity
- Risk: immunocompromised, immigrant communities, TB contacts, recent travel to endemic area
- Raised ESR/CRP, MRI spine + bone biopsy for diagnosis
- Radiation to back (tearing quality)
- Pulsatile abdominal sensation
- Risk: male, age > 65, hypertension, smoking
- Acute severe back + abdominal pain = ruptured AAA until proven otherwise — EMERGENCY
Blocked / Runny Nose ▼
- Duration (acute vs chronic)
- Unilateral vs bilateral (unilateral = more concerning)
- Discharge character (clear, mucopurulent, blood-stained)
- Constant vs intermittent
- Seasonal vs perennial
- Loss of smell (anosmia)
- Seasonal (grass: May–Jul; tree pollen: Mar–May)
- Perennial (house dust mite, pet dander)
- Bilateral watery discharge, sneezing, nasal itch
- Associated eye itch / watering (rhinoconjunctivitis)
- Atopic history (eczema, asthma, hayfever)
- Total nasal obstruction / anosmia suggests polyps
- Acute URTI (bilateral, mucopurulent after 2–4 days — normal, not antibiotic indication)
- Associated sore throat, fever, malaise
- Self-limiting 7–10 days
- Purulent discharge after 4 days is normal viral course — explain to patient
- Facial pain / pressure (frontal, maxillary, periorbital)
- Purulent nasal discharge
- Anosmia
- Dental pain upper jaw (maxillary sinusitis)
- Worse on bending forward
- Biphasic illness (initial improvement then worsening = likely secondary bacterial)
- Complications: periorbital cellulitis, orbital abscess, meningitis (rare — urgent)
- Almost always bilateral (unilateral polyp = EXCLUDE MALIGNANCY)
- Significant anosmia (often complete)
- Associated: asthma + aspirin/NSAID sensitivity = Samter's triad
- Pale, smooth, grape-like on rhinoscopy
- ⚠️ Unilateral polyp in older patient, especially woodworkers = sinonasal malignancy risk — adenocarcinoma in hardwood workers (COSHH risk, RIDDOR reportable)
- Refer any unilateral polyp / bleeding polyp urgently
- Vasomotor rhinitis: non-allergic triggers (temperature, smell, alcohol, emotion)
- Rhinitis medicamentosa: rebound congestion from decongestant spray overuse (> 5–7 days use)
- Cocaine use: septal perforation, anosmia, epistaxis, atrophic rhinitis
- CSF rhinorrhoea: clear watery unilateral discharge post-head trauma, halo test on filter paper — risk of meningitis
- Foreign body (children): unilateral, offensive odour
- Hypothyroidism: nasal mucosal oedema
- Pregnancy rhinitis: oestrogen-mediated
Blurred Vision ▼
- Sudden vs gradual onset
- Unilateral vs bilateral
- Blur vs distortion (wavy lines = metamorphopsia) vs missing area (scotoma) vs double vision (diplopia = different issue)
- Painless vs painful
- Flashes / floaters / curtain / shadow associated?
- Curtain or shadow descending or rising = retinal detachment until proven otherwise
- Same-day emergency ophthalmology referral
- Preceded by floaters ± flashes (photopsias)
- Risk factors: myopia, trauma, previous detachment, Marfan's, post-cataract surgery
- Also acute angle closure glaucoma: severe pain + red eye + halo + fixed mid-dilated pupil + nausea
- New floaters alone (cobwebs, dots) = posterior vitreous detachment (PVD — usually benign ageing)
- Floaters + flashes = retinal tear risk — same-day referral
- Floaters + flashes + visual field loss = retinal detachment — EMERGENCY
- Dark floaters in a diabetic = vitreous haemorrhage — urgent referral
- Large shower of floaters = retinal tear or haemorrhage
- Monocular diplopia (persists with fellow eye covered): cataract, refractive error, dry eye, corneal — OCULAR cause
- Binocular diplopia (disappears when covering one eye): cranial nerve palsy, thyroid eye disease, myasthenia gravis, INO (MS)
- CN III: down and out, complete ptosis, PUPIL DILATED (surgical — posterior communicating artery aneurysm — EMERGENCY)
- CN III sparing pupil: DM, hypertension (ischaemic) — less urgent but still refer
- CN VI: fails to abduct, horizontal diplopia on lateral gaze
- CN IV: vertical diplopia, worse on downgaze, head tilt, post-trauma common
- MG: fatigable ptosis / diplopia, worse at end of day, ice pack test positive
- CRAO (central retinal artery occlusion): sudden painless profound visual loss, cherry red spot on pale retina — EMERGENCY (ocular stroke, 90-min window)
- BRAO (branch): sector loss, less severe, embolic (AF, carotid, cardiac)
- CRVO (central vein): 'stormy sunset' fundus, widespread flame haemorrhages, disc oedema, variable loss
- BRVO (branch): sector haemorrhages, variable loss, associated hypertension
- All arterial occlusions: investigate embolic source (ECG/AF, echo, carotid Doppler, lipids, BP, diabetes, thrombophilia)
- Refractive error (myopia, hyperopia, presbyopia) — most common overall
- Cataract: cloudy, glare, faded colours, halos, frequent glasses change
- AMD: central vision loss, distortion (Amsler grid), wet = urgent anti-VEGF
- Glaucoma: peripheral loss, high IOP, optic disc cupping (insidious — regular screening)
- Diabetic maculopathy / retinopathy: annual screening, blurring + floaters
- Dry eye: fluctuating blur, relieved by blinking, worse in morning
- Optic neuritis: painful, unilateral, colour desaturation (red), worse with heat (Uhthoff) — MS
- Temporal arteritis: > 50 years, sudden loss, preceding amaurosis fugax, ESR/CRP elevated — STEROIDS SAME DAY
- Migraine visual aura: zigzag/fortification spectrum, 15–30 minutes, then headache
Breast Lump / Breast Pain ▼
- Duration
- Location (quadrant)
- Hard vs soft
- Mobile vs fixed
- Irregular vs smooth border
- Change in size
- Skin dimpling / tethering
- Peau d'orange
- Nipple discharge (colour, blood-stained)
- Nipple inversion (recent)
- Skin ulceration
- Axillary lymphadenopathy
- Arm swelling (lymphoedema)
- Bone pain
- Breathlessness
- Weight loss
- Cyclical vs non-cyclical pain
- Relation to menstrual cycle
- Pregnancy / breastfeeding
- HRT / OCP use
- Family history: breast / ovarian cancer, BRCA1/2
- Previous breast problems / surgery / biopsy
Chest Pain ▼
- Location, radiation (left arm, jaw, neck, back)
- Character (crushing, tight, pressure, heavy)
- Stable angina: predictable, exertional, resolves with GTN / rest
- Unstable angina: chest pain at rest, minimal exertion, increasing frequency/severity (crescendo pattern)
- NSTEMI: like unstable angina but significant troponin rise, no ST elevation
- STEMI: complete occlusion, persistent ST elevation, major troponin rise, thrombolysis/primary PCI
- Key differentiators: pain at rest? Worsening/more frequent than usual? Duration > 20 min? Failed GTN?
- Sweating, nausea, breathlessness, palpitations
- Previous MI / cardiac history
- Risk: HTN, DM, hyperlipidaemia, smoking, family history
- Pleuritic (worse on deep breath / cough)
- Cough / haemoptysis
- Fever
- Recent immobility / long-haul travel
- Leg swelling / tenderness (DVT)
- OCP / HRT / pregnancy
- Tearing / ripping / shearing character
- Radiation to back (interscapular)
- Sudden onset, severe
- Hypertension history
- Marfan's / connective tissue disease
- Unequal blood pressures / pulses
- Relation to food / posture
- Acid regurgitation / waterbrash
- Worse lying flat / bending
- Dysphagia
- Response to antacids (does NOT rule out cardiac)
- Reproducible on palpation
- Worse with movement / position change
- Localised tenderness
- Recent injury / prolonged coughing
- Worse lying flat
- Better leaning forward
- Recent viral illness / fever
- Pericardial rub on auscultation
- Tingling (hands, lips)
- Hyperventilation
- Palpitations
- Recent stressor
- Previous panic attacks
Confusion / Acute Delirium ▼
- Fever
- LRTI (cough, breathlessness)
- UTI (dysuria, frequency)
- Wound / cellulitis
- Recent healthcare contact
- Diabetes (hypoglycaemia / DKA)
- Thyroid disease
- Liver failure / hepatic encephalopathy
- Renal failure
- Hypo/hypernatraemia
- Hypercalcaemia
- Stroke / TIA history
- Seizures (post-ictal)
- Meningism (headache, neck stiffness, photophobia)
- Focal deficit
- Head trauma
- Dementia history
- Opioids
- Anticholinergics (TCAs, antihistamines, bladder medications)
- Benzodiazepines
- Steroids
- Alcohol (intoxication / withdrawal)
- Recreational drugs
- Recent surgery / anaesthesia
- Urinary retention (elderly men)
- Constipation / faecal impaction
- Pain (inadequately managed)
- Dehydration
- B12 / thiamine deficiency
- Environmental change
Constipation ▼
- Duration
- Stool frequency
- Stool consistency (Bristol Stool Chart 1–2)
- Straining
- Incomplete evacuation / tenesmus
- Blood / mucus in stool
- Fluid intake (< 2L per day common)
- Dietary fibre
- Physical activity
- Recent change in diet or routine
- Pregnancy
- Change in bowel habit > 6 weeks (new, unexplained, especially > 45 years)
- Rectal bleeding / melaena
- Unexplained weight loss
- Abdominal mass
- Iron deficiency anaemia with bowel symptoms
- Tenesmus
- Family history: CRC, Lynch syndrome, FAP
- Opioids (most common drug cause)
- Calcium channel blockers
- Iron supplements
- Antacids (aluminium-containing)
- Anticholinergics / TCAs
- Antipsychotics
- Hypothyroidism: cold intolerance, weight gain, dry skin, fatigue
- Hypercalcaemia: thirst, polyuria, bone pain, confusion
- Diabetes (autonomic neuropathy)
- Parkinson's disease
- Spinal cord pathology
- Autonomic neuropathy
- Anxiety / depression
- Eating disorder / food restriction
- Poor toilet access / ignoring urge
Cough ▼
- Duration (acute < 3 weeks; subacute 3–8 weeks; chronic > 8 weeks)
- Dry vs productive
- Sputum colour
- Haemoptysis
- Timing (nocturnal, morning, positional)
- Wheeze
- Breathlessness
- Fever / pleuritic chest pain
- Exercise tolerance
- Smoking (pack years)
- Occupational exposure (dust, asbestos, fumes, animals)
- Bird / cat exposure (hypersensitivity pneumonitis)
- TB contacts / travel
- Night sweats / weight loss (TB, malignancy)
- Orthopnoea / PND
- Ankle swelling
- Palpitations
- Post-nasal drip
- Hoarseness
- Sinus symptoms
- Stridor (urgent)
- Heartburn / acid reflux
- Relation to meals / lying flat
- ACE inhibitor (dry cough, 10–20%, weeks to months after starting)
- Beta blockers (bronchospasm)
- Aspirin / NSAIDs (AERD)
Diarrhoea ▼
- Duration and onset
- Frequency per day
- Blood / mucus in stool
- Nocturnal diarrhoea (organic cause)
- Tenesmus
- Steatorrhoea (pale, fatty, floating, offensive)
- Fever / vomiting
- Food history (food poisoning)
- Travel history
- Contact with symptomatic others
- Recent antibiotics (C. difficile)
- HIV / immunosuppressed
- Bloody diarrhoea
- Abdominal cramps
- Weight loss
- Perianal disease
- Mouth ulcers
- Joint pains, eye symptoms (uveitis), skin (erythema nodosum)
- Bloating / wind
- Alternating with constipation
- Relief on defecation
- Stress link
- No blood, no weight loss, no nocturnal symptoms
- Pale, fatty, floating, offensive stools
- Weight loss despite normal/increased appetite
- Previous bowel surgery
- Coeliac features (bloating, fatigue, iron deficiency)
- Hyperthyroid symptoms
- Addisonian features
- Antibiotics, metformin, laxatives, PPIs, SSRIs, magnesium antacids
- Change in bowel habit > 6 weeks (especially > 45)
- Rectal bleeding
- Weight loss
- Abdominal mass
- Iron deficiency anaemia
Dizziness / Vertigo ▼
- True vertigo (room spinning) vs presyncope (going to faint) vs disequilibrium (unsteady) vs light-headedness
- Onset (sudden vs gradual)
- Duration of episodes: seconds (BPPV) vs minutes-to-hours (Menière's) vs constant/days (neuritis) vs persistent central
- Nausea / vomiting
- Associated hearing loss or tinnitus (key differentiator)
- Very brief episodes (< 1 minute — usually 10–30 seconds)
- Provoked by specific head movements: lying down, rolling over in bed, looking up
- Latency (starts 2–5 seconds after head movement)
- Fatigability (same movement repeated = less intense vertigo)
- No hearing loss, no tinnitus
- Dix-Hallpike test positive (posterior canal — most common)
- Treatment: Epley manoeuvre (highly effective)
- Single episode of severe, constant vertigo lasting days (not seconds or hours)
- Gradual onset over hours, then persists for days to weeks
- NO hearing loss (differentiates from labyrinthitis)
- NO tinnitus
- Often follows viral URTI (few days later)
- Head impulse test positive (catch-up saccade on rapid head thrust to affected side)
- Spontaneous horizontal nystagmus, fast component away from lesion
- Treatment: steroids if early (< 72h), vestibular rehabilitation exercises
- Same as vestibular neuritis BUT associated WITH hearing loss AND tinnitus (cochlear involvement)
- Viral or bacterial (bacterial = urgent — risk of spread)
- Both vestibular and cochlear function affected
- Episodic attacks of: vertigo + tinnitus + fluctuating hearing loss + aural fullness/pressure (all FOUR features = classic)
- Episodes: 20 minutes to several hours
- Low-frequency SNHL (early — differentiates from presbyacusis which is high-frequency)
- Tinnitus: often described as roaring or low-pitched
- Progressive SNHL over time
- Triggers: high sodium diet, caffeine, stress, alcohol, weather change
- Treatment: dietary sodium restriction, betahistine, diuretics, intratympanic steroids/gentamicin
- Recurrent episodes of vertigo + migrainous symptoms (headache, photophobia, phonophobia)
- Can occur without headache (pure vestibular migraine)
- Can mimic BPPV but: does NOT fatigue with repeat Dix-Hallpike
- Often misdiagnosed — consider in any recurrent vertigo without clear BPPV pattern
- Migraine history often present
- Treatment: migraine prophylaxis
- Sudden onset without provoking head movement
- Diplopia, dysarthria, dysphagia, facial numbness, limb ataxia
- Severe persistent headache
- New persistent horizontal gaze nystagmus OR vertical nystagmus (always pathological — central)
- Head impulse test NEGATIVE in stroke (vs positive in peripheral = reassuring)
- Age > 60 + vascular risk factors + sudden vertigo = AICA/PICA stroke until proven otherwise
- Previous stroke / TIA
- HINTS exam (Head Impulse, Nystagmus, Test of Skew) — differentiates peripheral from central
- Orthostatic symptoms (worse on standing — orthostatic hypotension)
- Medication (antihypertensives, diuretics, aminoglycosides)
- Anaemia
- Anxiety / hyperventilation
Dysphagia (Swallowing Difficulty) ▼
- Solids only (mechanical) vs solids and liquids (neurological)
- Progressive vs intermittent
- Level (throat, mid-chest, lower chest / epigastric)
- Odynophagia (pain on swallowing)
- Duration and progression
- Regurgitation (undigested = oesophageal)
- Heartburn / GORD
- Weight loss
- Haematemesis
- Difficulty initiating swallow
- Drooling / aspiration / choking
- Nasal regurgitation
- Dysarthria / slurred speech
- Previous stroke / Parkinson's / MND / MS
- Globus sensation
- Voice change / hoarseness
- Neck lump
- Stridor (urgent)
- Weight loss (malignancy)
- Iron deficiency (Plummer-Vinson / Patterson-Brown-Kelly)
- Skin tightening / Raynaud's (systemic sclerosis)
- Eosinophilic oesophagitis (young atopic, food impaction)
Ear Pain / Otalgia ▼
- Duration
- Unilateral vs bilateral
- Discharge (colour, odour, blood)
- Onset (acute vs chronic)
- Hearing loss
- Tinnitus
- Vertigo
- Recent swimming (otitis externa)
- Recent URTI (otitis media)
- Previous surgery / grommets
- Facial weakness (cholesteatoma — refer urgently)
- Itch (OE)
- Dental pain / recent dental work
- Jaw / TMJ pain
- Sore throat / tonsillitis / quinsy
- Cervical spine pain
- Tongue or mouth ulcer
- Neck lump
- Diabetes / immunosuppressed (necrotising / malignant OE)
- Vesicular rash on pinna / canal (Ramsay Hunt — herpes zoster oticus — facial nerve risk)
- Mastoid tenderness / swelling (mastoiditis — urgent)
- Foreign body (children)
Elbow Pain ▼
- Location (lateral, medial, posterior, anterior)
- Onset (acute vs insidious)
- Character (aching, burning, electric shock)
- Radiation (forearm, fingers)
- Occupation / sport / repetitive activity
- Previous elbow injuries
- Lateral epicondyle point tenderness
- Onset: repetitive wrist extension (racquet sports, screwdrivers, keyboard)
- Pain radiating down extensor forearm
- Weak grip / pain lifting coffee cup
- Positive Cozen's test (resisted wrist extension)
- Positive Mills' test (passive wrist flexion + extended elbow)
- Medial epicondyle tenderness
- Onset: repetitive wrist flexion (golf, hammering, throwing)
- Pain radiating down flexor forearm
- Positive resisted wrist flexion test
- ⚠️ Exclude cubital tunnel (ulnar nerve tingling — see below)
- Swelling directly over olecranon tip (fluctuant, well-defined)
- Acute trauma (fall onto elbow)
- Repetitive pressure ('student's / miner's elbow')
- Gout: acute onset, warm, erythematous — aspirate (crystals)
- Infection / septic bursitis: fever, erythema, pain — aspirate to exclude
- RA: associated systemic features
- Tingling / numbness: little finger and medial ring finger
- Worse with elbow flexion (phone, driving, sleeping)
- Cubital tunnel test (full elbow flexion 1 min reproduces symptoms)
- Ulnar nerve tenderness at medial epicondyle
- Hypothenar wasting (late)
- Froment's sign
- Radial head fracture: fall on outstretched hand, lateral elbow pain, limited supination
- OA elbow: limited extension, previous fracture / sport
- Referred C6/7 radiculopathy: radiation from neck
- Distal biceps rupture: antecubital fossa, 'pop', weak supination
Falls / Faints ▼
- Trip / mechanical: clear external cause, otherwise well — falls prevention, physio, environment
- True fall (no external cause): requires systematic investigation
- Faint (syncope): loss of consciousness with or without fall
- Always obtain witness account
- Prodrome: warmth, nausea, sweating, tunnel / greying vision (seconds before)
- Triggers: prolonged standing, heat, crowded spaces, pain, needles, emotion
- Rapid complete recovery
- Common in teenage girls: inadequate fluid intake through day (often only 1–2 glasses)
- Prolonged standing: school assemblies, queues, concerts
- Hot weather (vasodilation)
- Dehydration: not drinking enough — simple but often missed
- Symptoms on standing (lightheaded, grey vision)
- > 20 mmHg systolic drop within 3 minutes of standing
- Drug-induced (very common): antihypertensives, alpha blockers, diuretics, TCAs, antipsychotics, levodopa, sildenafil
- Dehydration / blood loss / sepsis
- Autonomic neuropathy: diabetes, Parkinson's, MSA
- Prolonged bed rest / deconditioning
- Sudden without warning (arrhythmia — long QT, AF, VT, complete heart block)
- During exertion (HOCM, aortic stenosis — dangerous)
- Chest pain / palpitations before
- Family history sudden cardiac death < 40 years
- Abnormal ECG
- Syncope lying or seated (cardiac until proven otherwise)
- Stroke / TIA: associated focal neurology (weakness, speech, vision — not isolated fall usually)
- Seizure: tongue biting (lateral), prolonged post-ictal confusion > 5 min, incontinence, tonic-clonic
- Drop attacks (vertebrobasilar): sudden fall without LOC, no warning, vertigo
- Carotid sinus hypersensitivity: collar turning, shaving (elderly)
- NPH: magnetic shuffling gait + urinary incontinence + cognitive decline
- Hypoglycaemia: diabetes, gradual onset, sweating, confusion
- Anaemia: exertional pre-syncope
- Addisonian / adrenal crisis
- Medication review (polypharmacy: antihypertensives, sedatives, diuretics)
- Vision impairment
- Peripheral neuropathy (loss of proprioception)
- Muscle weakness (sarcopenia, vitamin D deficiency)
- Environmental hazards (rugs, lighting, steps)
- Postural instability (Parkinson's, cerebellar)
- Continence issues (rushing to toilet)
- FRAX score / bone protection
Fatigue / Tiredness ▼
- Pallor, breathlessness, palpitations
- Heavy menstrual loss
- Rectal bleeding / melaena
- Diet: iron, B12, folate
- Weight change
- Cold / heat intolerance
- Hair / skin changes (thyroid)
- Polyuria / polydipsia (diabetes)
- Pigmentation / postural dizziness (Addison's)
- Low mood / anhedonia (depression)
- Sleep disturbance
- Recent stressors
- Anxiety / worry
- Concentration difficulties
- Fever / night sweats
- Lymphadenopathy
- Recent viral illness (EBV)
- HIV risk factors
- Joint pains / rash
- Exercise tolerance
- Breathlessness
- Orthopnoea / PND
- Alcohol history
- Jaundice
- Abdominal distension
- Snoring / apnoeas (OSA)
- Sleep quality / quantity
- Night shifts
- Weight loss
- Night sweats
- Lymphadenopathy
- Beta blockers, sedatives, opioids, statins (myopathy)
- Alcohol / recreational drugs
Fever / Pyrexia ▼
- Duration
- Rigors / chills
- Drenching night sweats
- Pattern (intermittent, continuous, relapsing)
- Respiratory (cough, breathlessness)
- Urinary (dysuria, frequency, loin pain)
- Skin / wound / cellulitis
- ENT (sore throat, ear pain)
- Abdominal / GI (pain, diarrhoea)
- CNS (headache, neck stiffness, photophobia — URGENT)
- Joints (hot swollen — septic arthritis URGENT)
- Travel history (malaria, dengue, typhoid, enteric fever)
- Animal contact (brucellosis, psittacosis)
- Recent hospital / IV access
- IV drug use (endocarditis)
- Sexual history (if relevant)
- Weight loss, night sweats, lymphadenopathy
- Previous or current malignancy
- Joint pains / rashes
- IBD symptoms
- Vasculitis features
- Diabetes, HIV, steroids, chemotherapy, splenectomy
Gait Problems / Walking Difficulty ▼
- Onset (acute vs insidious vs progressive)
- Unilateral vs bilateral
- Pain-related vs neurological
- Falls / near-misses
- Impact on daily function
- Short stance phase on affected side
- Hip, knee, ankle, or foot pain
- May be first sign of hip OA or Perthes (children)
- Circumduction of affected leg
- Arm held flexed at side
- Causes: stroke (sudden), MS, cerebral palsy
- Hyperreflexia, upgoing plantar (Babinski), clonus
- Spastic paraparesis (bilateral): MS, myelopathy — scissor gait
- Shuffling, small steps (festination — progressive acceleration)
- Reduced arm swing (unilateral early)
- Stooped posture
- Freezing (especially doorways)
- Retropulsion (falls backward)
- Associated: pill-rolling tremor, cogwheel rigidity, hypomimia
- Wide-based, staggering, unable to tandem walk
- Does NOT worsen markedly in dark (compare: sensory ataxia)
- Causes: MS, cerebellar stroke, alcohol (acute/chronic), antiepileptics
- Dysdiadochokinesis, intention tremor, nystagmus, dysarthria
- Stamping / high-stepping gait
- Markedly worse in the dark (removes visual compensation)
- Positive Romberg's sign
- Causes: peripheral neuropathy (DM, B12), posterior column disease
- Impaired vibration sense / proprioception, absent ankle jerks
- Exaggerated hip / knee flexion to clear foot
- Foot slap on landing
- Causes: common peroneal nerve palsy, L4/5 radiculopathy, MND (bilateral = early sign), CMT, GBS
- Weak ankle dorsiflexion and eversion
- Pelvis tilts down on swing phase (weak hip abductors)
- Bilateral: proximal myopathy (DMD, polymyositis, steroid, hypothyroid myopathy)
- Unilateral: hip OA, hip replacement, gluteal tendinopathy
- Positive Trendelenburg test
- MND: mixed UMN + LMN, foot drop + spasticity, fasciculations, NO sensory loss, progressive
- MS: variable (lesion-dependent), spastic + ataxic, Uhthoff's, fatigue, Lhermitte's sign
Haematuria (Blood in Urine) ▼
- Visible vs non-visible
- Painful vs painless (painless = malignancy until proven otherwise)
- Timing (initial, terminal, throughout)
- Clots
- Duration
- Dysuria / frequency / urgency (UTI)
- Loin to groin pain (ureteric stone)
- Suprapubic pain (bladder)
- Poor flow / hesitancy (prostate)
- Haematospermia
- Oedema, hypertension
- Recent sore throat (post-streptococcal GN)
- Joint pains / rash (SLE, vasculitis, IgA)
- Painless visible haematuria = URGENT 2ww referral (any age)
- Age > 45 with recurrent non-visible haematuria
- Smoking (bladder cancer risk)
- Occupational: aniline dyes, rubber industry
- Anticoagulants, cyclophosphamide
- Family history: polycystic kidneys, Alport
- Menstrual contamination (exclude)
Haemoptysis (Coughing Up Blood) ▼
- Volume (streaks vs cupful)
- Colour (bright red, rusty, pink frothy)
- Mixed with sputum or pure blood
- Distinguish from haematemesis and epistaxis
- Cough, breathlessness, wheeze
- Fever (LRTI, lung abscess)
- Night sweats / weight loss (TB, malignancy)
- Smoking (pack years)
- Occupational (asbestos)
- TB contacts / travel
- Pink frothy sputum (pulmonary oedema — urgent)
- DVT risk factors (PE)
- Cardiac history
- Epistaxis / nasal source
- Oral / gum bleeding
- Anticoagulants
- Vasculitis (Goodpasture's, GPA)
Hair Loss ▼
- Pattern (diffuse vs focal / patchy vs patterned)
- Rate and duration
- Scalp itch / pain / scaling
- Systemic illness / stress in preceding 3–6 months
- Nutritional habits
- Hair care practices (tight styles, chemicals, heat)
- Male: bitemporal recession + vertex (Hamilton-Norwood)
- Female: diffuse crown thinning, preserved frontal hairline (Ludwig)
- Gradual onset, strong family history
- Treatment: minoxidil (first-line OTC), finasteride (males), DHEAS screen in women
- Patchy, well-defined areas
- Exclamation mark hairs at patch margins
- Normal scalp appearance (no scarring)
- Associated: thyroid, vitiligo, T1DM, Addison's, atopy
- Nail changes (pitting, trachyonychia)
- Alopecia totalis (scalp) / universalis (whole body)
- Diffuse shedding, 2–4 months after trigger
- Triggers: childbirth, surgery, illness, high fever, crash diet, emotional stress, stopping OCP
- Handfuls in shower or on pillow
- Usually self-limiting 6–12 months
- Hypothyroidism: diffuse, brittle, eyebrow outer third loss
- Hyperthyroidism: fine, diffuse thinning
- Iron deficiency: check ferritin (not just Hb)
- B12 / zinc deficiency
- SLE: diffuse + 'lupus hairs' (frontal fringe)
- Secondary syphilis: moth-eaten pattern
- Chemotherapy (anagen effluvium — abrupt, during treatment)
- Anticoagulants (heparin, warfarin)
- Carbimazole, lithium, beta blockers, retinoids
- Tinea capitis: children, broken hairs, scaly patch
- Traction alopecia: tight hairstyles, frontal
- Scarring alopecias: lichen planopilaris, DLE — biopsy needed
- Diffuse androgenic thinning
- Hirsutism (face, chest)
- Irregular / absent periods
- Acne
- Raised androgens / LH:FSH
Hand Pain ▼
- Location (wrist, palm, dorsum, fingers, specific joint)
- Onset (acute vs chronic)
- Character (aching, burning, tingling, stiffness)
- Morning vs activity-related
- Dominant hand / occupation
- Heberden's nodes (DIP joint)
- Bouchard's nodes (PIP joint)
- 1st CMC joint (base of thumb) — pinch grip pain, squaring of thumb base
- Morning stiffness < 30 minutes
- Worse with activity, crepitus
- MCP and PIP joints (not DIP)
- Symmetrical, bilateral
- Morning stiffness > 1 hour
- Wrist synovitis, ulnar deviation (late)
- Systemic: fatigue, fever, weight loss
- Positive RF / anti-CCP
- Nocturnal tingling/numbness (waking classic)
- Thumb, index, middle, lateral ring (palmar — not back of hand)
- Does NOT affect little finger
- Thenar wasting (late)
- Tinel's / Phalen's positive
- Risk: pregnancy, hypothyroid, diabetes, RA, obesity
- Nerve conduction studies for diagnosis
- Radial wrist / radial styloid pain
- 1st dorsal compartment (APL + EPB)
- Finkelstein's test positive (thumb in palm, ulnar deviate)
- Common: new mothers, repetitive use
- Trigger finger: locking in flexion, nodule at A1 pulley, ring finger most common
- Dupuytren's: palmar cord, ring / little finger, painless contracture, alcohol / DM association
- Gout: 1st CMC joint (less common than MTP)
- Psoriatic arthritis: DIP involvement, nail pitting, dactylitis
- Ganglion: dorsal wrist, transilluminates, cystic
Headache ▼
- Onset (sudden thunderclap = SAH until proven otherwise)
- Duration
- Location (unilateral, bilateral, vertex, occipital, orbital)
- Character (throbbing, pressing, stabbing, burning)
- Severity
- Frequency and pattern
- Unilateral pulsating, moderate-severe
- Nausea / vomiting
- Photophobia / phonophobia
- Aura: visual zigzag, sensory, motor (< 1 hour)
- 4–72 hours duration
- Unable to continue activity
- Triggers (food, hormonal, sleep, stress, alcohol)
- Bilateral pressing / band-like
- Mild-moderate, not throbbing
- No nausea (or mild)
- Screen time / posture / stress link
- Unilateral periorbital, excruciating
- Autonomic: lacrimation, ptosis, miosis, rhinorrhoea, conjunctival injection
- Restlessness (cannot lie still)
- 15–180 minutes, cluster periods
- Nocturnal timing common
- Progressive worsening over days-weeks
- Worse lying down, morning
- Waking from sleep
- Vomiting without nausea
- Visual changes / papilloedema
- Focal neurology / cognitive change
- History of malignancy / immunosuppression
- Thunderclap — maximal in seconds
- 'Worst ever headache'
- During exertion / Valsalva
- Neck stiffness, photophobia
- LOC, vomiting
- Fever, neck stiffness, photophobia
- Non-blanching purpuric rash
- Reduced consciousness
- Scalp / temporal tenderness
- Jaw claudication
- Sudden visual loss — TREAT SAME DAY
- Proximal muscle ache (PMR)
- ESR/CRP elevated
- Analgesics > 10–15 days/month
- Daily / near-daily headache
- Headache on waking
Hearing Loss ▼
- Sudden vs gradual
- Unilateral vs bilateral
- Conductive vs sensorineural (Rinne's/Weber's)
- Tinnitus
- Vertigo
- Discharge / pain
- Occupation (noise exposure)
- Ototoxic medications
- Wax (most common GP cause)
- Otitis media with effusion (glue ear — children)
- Acute otitis media (painful, fever)
- Otosclerosis (young adult, bilateral, insidious, fixed malleus)
- TM perforation
- Cholesteatoma (refer urgently)
- Noise-induced (occupational, high-frequency loss, 4kHz notch)
- Presbyacusis: bilateral progressive high-frequency loss, age-related
- Sudden SNHL (≥ 30dB / ≥ 3 frequencies / 72h) = AUDIOLOGICAL EMERGENCY — same-day ENT (oral steroids within 24–72h)
- Acoustic neuroma: unilateral SNHL + tinnitus + balance, MRI IAMs
- Menière's: low-frequency SNHL + tinnitus + aural fullness + vertigo
- Viral (mumps, CMV, post-meningitis)
- Aminoglycosides (gentamicin, tobramycin)
- Cisplatin / carboplatin
- Loop diuretics (IV high dose)
- Quinine
- Vancomycin
- Glue ear (OME): most common 2–8 years, speech delay
- Congenital: TORCH, Connexin 26 (most common genetic SNHL)
- Post-meningitis: urgent audiology
- Neonatal screening (NHSP)
Heavy Menstrual Bleeding / Menstrual Problems ▼
- Cycle length and regularity
- Duration of bleeding
- Amount (clots, flooding, > 1 pad/hour = heavy)
- Intermenstrual bleeding
- Post-coital bleeding
- Dysmenorrhoea (primary vs secondary — secondary = endometriosis)
- Deep dyspareunia (endometriosis)
- Pelvic pain / heaviness (fibroids)
- Vaginal discharge
- LMP / last smear
- Contraception
- Previous STIs / PID
- Hypothyroid symptoms
- Acne / hirsutism / irregular cycles (PCOS)
- Galactorrhoea (hyperprolactinaemia)
- Bruising / bleeding elsewhere (von Willebrand)
- Family history bleeding disorder
- Epistaxis
- Anticoagulants, copper IUD, steroids, tamoxifen
- Fertility concerns
- Perimenopausal symptoms
- BMI (obesity → endometrial cancer risk)
Hip Pain ▼
- Location: groin / anterior (true hip) vs lateral hip vs posterior (lumbar / SI referral)
- Onset (acute vs insidious)
- Radiation to knee (true hip pain classically radiates to knee)
- Weight-bearing / antalgic gait
- Morning stiffness duration
- Age (child / young adult / middle-aged / elderly — very different differentials)
- Osteoarthritis: groin pain, radiation to knee, loss of internal rotation, morning stiffness < 30 min
- Avascular necrosis (AVN): risk — steroids (even short courses), alcohol, SLE, sickle cell, trauma, Caisson's disease
- Labral tear: deep groin / acetabular pain, clicking, giving way (FAI — femoroacetabular impingement)
- Hip stress fracture: groin pain on weight bearing, elderly osteoporotic / young female athlete
- Septic arthritis: hot, swollen, fever, systemically unwell — EMERGENCY
- Transient synovitis (children): acute, post-viral, limp (most common cause of acute hip pain in children 3–10)
- Perthes disease (4–10 years): AVN femoral head, limp, limited abduction and internal rotation
- SUFE (adolescent): overweight, knee pain (referred), limp — urgent X-ray frog-leg lateral
- Greater trochanteric pain syndrome (GTPS): lateral hip ache, tenderness over greater trochanter
- Worse lying on affected side, going up stairs, crossing legs
- Gluteal tendinopathy (gluteus medius / minimus)
- FABER and FADIR tests positive
- Common: middle-aged women, wide pelvis, runners
- Previously called 'trochanteric bursitis' — true bursitis is less common than tendinopathy
- Lateral femoral cutaneous nerve (LFCN, L2–L3) compression
- Burning, tingling, numbness on anterior and lateral thigh (not below knee)
- NO motor deficit (purely sensory nerve)
- Common: pregnancy (third trimester), obesity, tight waistbands / belts, prolonged standing
- Reproduction: pressure below inguinal ligament medial to ASIS
- Usually self-limiting — remove cause; steroid injection if persistent
- Age > 50 (almost always)
- BILATERAL shoulder AND hip girdle aching and stiffness
- Morning stiffness > 45 minutes
- Difficulty raising arms above head / getting off toilet or chair
- No muscle weakness (distinguish from myositis)
- Elevated ESR (usually > 40) and CRP
- Dramatic response to prednisolone 15mg (diagnostic and therapeutic)
- Always exclude GCA (jaw claudication, visual symptoms, scalp tenderness)
- Exclude malignancy and other inflammatory arthritis
- Lumbar spine / SI joint: posterior hip / buttock pain, radiation down leg
- L3 radiculopathy: anterior thigh pain — can mimic hip disease
- Pubic symphysis: medial groin pain (athletes, pregnancy)
Hoarse Voice ▼
- Duration (acute vs chronic — > 3 weeks unexplained = 2ww referral)
- Onset (sudden vs gradual)
- Sore throat / pain
- Dysphagia
- Breathlessness / stridor
- Smoking history (major risk factor for laryngeal cancer)
- Occupation (professional voice user: singer, teacher, lecturer)
- Recent intubation / anaesthesia
- Acute laryngitis: URTI, sudden, self-limiting (avoid voice rest > 2 weeks use)
- Vocal cord nodules / polyps: voice overuse (bilateral nodules), persistent change
- Vocal cord palsy: breathy voice, weak cough, aspiration risk — investigate cause
- Reinke's oedema: smoker, bilateral fluid-filled cords, very low-pitched rough voice
- GORD / LPR: morning hoarseness, throat clearing, globus, acid taste
- Left RLN has long mediastinal course — vulnerable to many causes
- Lung cancer (upper / middle lobe — most feared)
- Mediastinal lymphoma
- Thoracic aortic aneurysm
- Thyroid cancer / large goitre
- Post-thyroidectomy
- Pericarditis / cardiac surgery
- Bovine cough (no explosive first phase)
- Hypothyroidism: low, croaky, slow speech
- Systemic sclerosis: laryngeal involvement (rare)
- Unexplained hoarseness > 3 weeks (age > 45)
- Stridor (partial obstruction — immediate)
- Dysphagia + hoarseness
- Haemoptysis + hoarseness
- Weight loss with voice change
- Neck lump + hoarseness
- Smoking + alcohol history with persistent change
Indigestion / Dyspepsia / Heartburn ▼
- Location (epigastric, retrosternal)
- Character (burning, aching, bloating, heaviness)
- Duration
- Relation to food (before, after, specific foods)
- Relation to posture (worse lying flat, bending)
- Acid regurgitation / waterbrash
- Dysphagia
- Nausea / vomiting / haematemesis
- Melaena
- Appetite loss / early satiety
- Weight loss
- Bloating / bowel habit change
- Dysphagia
- Unexplained weight loss
- Persistent vomiting
- Haematemesis / melaena
- Epigastric mass
- Age > 55 with new dyspepsia
- Iron deficiency anaemia
- NSAIDs / aspirin (always ask)
- Steroids
- Bisphosphonates
- Iron supplements
- Nitrates
- Alcohol, smoking, caffeine
- Fatty food intolerance + RUQ pain (gallstones)
- H. pylori risk
- Functional dyspepsia (stress, no red flags)
Itching (Severe) / Pruritus ▼
- Duration
- Generalised vs localised
- Rash vs no rash (pruritus sine materia = systemic cause likely)
- Timing (nocturnal = scabies, eczema, uraemia; after hot bath = polycythaemia vera)
- Household contacts (scabies)
- Obstructive jaundice: bile salts in skin, severe, palms/soles, worse at night
- Primary biliary cholangitis (PBC): middle-aged women, insidious
- PSC: associated with IBD (UC)
- Drug-induced cholestasis
- Dark urine + pale stools (obstructive)
- Pruritus in pregnancy (any trimester, especially third)
- Palms and soles, nocturnal, intense
- No primary rash
- Risk of stillbirth, premature labour, fetal arrhythmia
- Urgent: LFTs + bile acids — refer obstetrics
- Induction at 37 weeks standard
- CKD (uraemic pruritus): widespread, nocturnal, dialysis patients
- Associated uraemic features (fatigue, oedema, foamy urine)
- Polycythaemia vera: aquagenic pruritus (after hot bath — almost pathognomonic)
- Hodgkin's lymphoma: severe, part of B symptoms
- Iron deficiency anaemia (without rash)
- Myeloma / leukaemia
- Iron supplements (common)
- Opioids (histamine release)
- ACE inhibitors
- Antibiotics (co-amoxiclav, erythromycin)
- Chloroquine / hydroxychloroquine (delayed weeks to months)
- Statins, allopurinol, thiazide diuretics
- Tamoxifen
- Eczema, psoriasis, lichen planus
- Scabies: burrows (web spaces, wrists, genitalia), nocturnal, household contacts
- Urticaria (wheals, risk of angioedema)
- Dry skin (xerosis): elderly, atopy
- Thyroid disease (both hypo and hyper)
- Diabetes (vulvar/anal pruritus, poorly controlled)
- HIV / AIDS (prurigo nodularis)
Jaundice ▼
- Duration
- Dark urine, pale stools, pruritis (obstructive)
- Speed of onset
- Associated pain (colicky RUQ = stones; painless = malignancy)
- Pallor (haemolysis)
- Family history: sickle cell, G6PD, hereditary spherocytosis
- Recent blood transfusion
- Travel (malaria)
- Alcohol history
- IV drug use / needle sharing / tattoos / piercings
- Sexual history (Hep B)
- Travel (Hep A, E)
- Previous liver disease
- Colicky RUQ pain (gallstones)
- Painless progressive jaundice + weight loss (pancreatic cancer)
- Fever + rigors + jaundice (Charcot's triad = ascending cholangitis — URGENT)
- Abdominal mass
- Paracetamol overdose
- Co-amoxiclav, flucloxacillin, antituberculous drugs
- Herbal remedies / supplements
- Statins, methotrexate
Joint Pain / Arthralgia ▼
- Number of joints (mono/oligo/poly)
- Distribution (small: MCP/PIP/wrist; large: knee/hip; axial: spine/SI)
- Symmetrical vs asymmetrical
- Onset (acute vs insidious)
- Morning stiffness duration
- Swelling / warmth / redness
- Morning stiffness > 30–60 min (RA)
- Symmetrical small joints (RA)
- Psoriasis, family history, IBD symptoms (SpA)
- Previous STI (reactive arthritis)
- Eye symptoms (uveitis)
- Age / obesity, large weight-bearing joints
- Morning stiffness < 30 min
- Worse with activity, Heberden's / Bouchard's nodes
- Acute single joint (1st MTP, ankle, knee)
- Exquisitely tender, red, hot
- Triggers: alcohol, red meat, diuretics, recent illness
- Tophi
- Pseudogout: elderly, knee/wrist, calcium pyrophosphate
- Hot, red, swollen single joint + fever
- Systemically unwell, IV drug use, skin break
- STI risk (gonococcal)
- Joint aspiration urgently — do not delay
- Rash, fever, weight loss, oral ulcers (SLE, Still's)
- Raynaud's (systemic sclerosis, SLE)
- Referred pain: hip → knee; lumbar → hip
Knee Pain ▼
- Onset: acute (twisting) vs insidious (overuse) vs acute-on-chronic
- Mechanism: twisting, hyperextension, direct blow
- Swelling: immediate (< 2 hours = haemarthrosis) vs delayed 12–24h (= effusion)
- Location: anterior, medial, lateral, posterior
- Locking / giving way / clicking
- Weight-bearing ability
- Haemarthrosis (< 2–4 hours): ACL tear (~50% of traumatic haemarthroses), tibial plateau fracture, peripheral meniscal tear, patellar dislocation
- — Studies show 47–64% of acute traumatic haemarthroses have an ACL tear (Casteleyn & Handelberg, 1996; Noyes et al, 1980)
- Delayed effusion (12–24h): meniscal tear (synovial fluid), capsular injury, contusion
- Ottawa Knee Rules: X-ray if age ≥ 55, fibula head tender, isolated patellar tender, unable to flex 90°, unable to weight bear 4 steps
- ACL tests: Lachman (best), anterior drawer, pivot shift
- Cruciate history: 'pop' at time of injury, immediate swelling, unable to continue playing
- Medial more commonly injured than lateral
- Joint line tenderness (medial or lateral)
- McMurray's test, Thessaly test (standing rotation at 20°)
- Locked knee = bucket-handle tear (cannot fully extend — urgent)
- Mechanical symptoms: clicking, catching, giving way
- Delayed swelling after activity
- Baker's cyst (posterior)
- Degenerative meniscal tears in older patients (may be incidental on MRI)
- Diffuse anterior knee pain
- Worse stairs, prolonged sitting ('theatre sign')
- Crepitus
- Young active patients
- Patellar tendinopathy ('jumper's knee'): inferior pole, younger athletes
- Osgood-Schlatter: adolescents, tibial tuberosity pain/swelling
- Age > 50, obesity, previous injury
- Medial compartment most common
- Morning stiffness < 30 min
- Worse with activity
- Varus deformity (bow-legged) as progresses
- Gout / pseudogout (pseudogout 2nd most common site after wrist)
- Septic arthritis: hot, swollen, fever — EMERGENCY
- Bursitis: prepatellar (carpet layer's)
- Referred from hip (always examine hip when knee pain, especially in children)
Leg Pain / DVT Query ▼
- Unilateral calf pain, swelling, warmth, erythema
- Wells score: immobility/surgery, active malignancy, previous DVT, long travel, pregnancy/postnatal, OCP/HRT, paralysis/cast
- Sudden breathlessness
- Pleuritic chest pain
- Haemoptysis
- Tachycardia
- Risk factors as above
- Claudication distance, rest pain
- Colour changes (pallor, mottling)
- Non-healing ulcers / gangrene
- Risk: smoking, DM, HTN, hyperlipidaemia
- Muscle cramp (nocturnal)
- Sciatica (lumbar radiation, dermatomal)
- Baker's cyst (mimics DVT)
- Trauma / compartment syndrome
- Bilateral, varicose veins
- Skin changes (lipodermatosclerosis, varicose eczema)
- Previous DVT
Low Mood / Depression ▼
- Persistent low mood > 2 weeks
- Anhedonia
- Fatigue / low energy
- Sleep disturbance (early morning wakening, insomnia, hypersomnia)
- Appetite / weight change
- Concentration difficulties
- Psychomotor retardation / agitation
- Reduced libido
- Worthlessness / guilt
- Hopelessness
- Negative automatic thoughts
- Previous elevated mood episodes
- Reduced sleep without tiredness
- Grandiosity, risky behaviour
- Passive vs active suicidal ideation
- Plan, intent, means
- Previous attempts
- Protective factors
- Hypothyroidism, anaemia, chronic illness
- Medication: beta blockers, OCP, steroids
- Life events, trauma, abuse
- Social support / isolation
- Alcohol / substances
Lower Urinary Tract Symptoms — Men (LUTS) ▼
- Poor stream, hesitancy, straining
- Intermittent stream, post-void dribbling
- Incomplete emptying, urinary retention
- Frequency (day and night)
- Nocturia, urgency, urge incontinence
- Dysuria, haematuria
- Fever / rigors (prostatitis, pyelonephritis)
- Perineal / scrotal pain (prostatitis)
- Painless visible haematuria
- Weight loss, bone pain
- PSA history
- Double incontinence
- Neurological symptoms (MS, Parkinson's)
- Saddle anaesthesia
- Anticholinergics, antihistamines, opioids (retention)
- Alpha blockers, 5-alpha reductase inhibitors (current treatment)
Memory Problems / Cognitive Decline ▼
- Onset (insidious = Alzheimer's; sudden/stepwise = vascular)
- Rate of progression
- Short-term vs long-term memory
- Informant history essential
- Impact on ADLs
- Memory (repeating questions)
- Language (word-finding)
- Visuospatial (getting lost, driving)
- Executive function (planning, decisions)
- Personality / behavioural change
- Disinhibition (frontal)
- Hypothyroidism, B12/folate deficiency
- Depression (pseudodementia)
- UTI (acute confusion in elderly)
- Medication (anticholinergics, benzodiazepines)
- Alcohol excess
- Normal pressure hydrocephalus (gait + incontinence + dementia)
- Subdural haematoma (head trauma — even minor in elderly)
- Stroke / TIA, hypertension, diabetes, AF, hyperlipidaemia
- Driving (DVLA notification)
- Living alone, cooking, medication management
- Financial decision-making, wandering
- Carer burden, support, power of attorney
Nausea and Vomiting ▼
- Duration and frequency
- Timing (morning = pregnancy; nocturnal = raised ICP; constant)
- Vomit appearance (bile, haematemesis, coffee-ground, undigested food)
- Projectile (raised ICP, pyloric stenosis)
- Dehydration features
- Abdominal pain (location)
- Diarrhoea, last bowel motion
- Absolute constipation (obstruction)
- Haematemesis / melaena
- Appetite / weight loss
- Headache (raised ICP)
- Vertigo
- Meningism (neck stiffness, photophobia — URGENT)
- Focal neurology
- LMP (always in women of reproductive age)
- Pregnancy test
- Hyperemesis (dehydration, ketonuria)
- Diabetes (DKA, hypoglycaemia)
- Renal failure
- Hypercalcaemia
- Chest pain (nausea = classic MI feature — especially inferior)
- Diaphoresis
- Opioids, antibiotics, digoxin toxicity, chemotherapy, NSAIDs
- Alcohol, labyrinthitis, anxiety
Neck Lump / Lymphadenopathy ▼
- Duration, growing / static, painful vs painless
- Hard vs soft vs rubbery vs fluctuant
- Fixed vs mobile
- Position (anterior, posterior triangle, midline, supraclavicular)
- Recent URTI / sore throat / dental abscess
- Fever (EBV, CMV, toxoplasmosis)
- HIV risk (seroconversion)
- TB contacts / country of origin (posterior triangle)
- Cat scratch (Bartonella)
- Painless, hard, fixed, irregular
- Weight loss, night sweats
- Alcohol-induced node pain (Hodgkin's — specific)
- Smoking / alcohol (head and neck SCC)
- Left supraclavicular = Virchow's node (abdominal malignancy)
- Dysphagia / hoarseness
- Midline (thyroglossal — moves on tongue protrusion)
- Moves on swallowing (thyroid origin)
- Hyper / hypothyroid symptoms
- Neck irradiation history
- Relation to meals / eating (stone)
- Dry mouth / eyes (Sjögren's)
- Branchial cyst (young adult, lateral neck)
- Cystic hygroma (children)
Neck Pain ▼
- Onset (acute vs gradual)
- Trauma (whiplash)
- Character (ache, stiffness, sharp, burning)
- Radiation (shoulder, arm — radiculopathy)
- Morning stiffness
- Range of movement
- Arm weakness / numbness / tingling (dermatomal)
- C6: thumb/index/lateral forearm
- C7: middle finger / posterior arm
- C8: ring/little finger / medial forearm
- Hand clumsiness (myelopathy)
- Bladder / bowel dysfunction (myelopathy — RED FLAG)
- Lhermitte's sign
- Bilateral limb symptoms (myelopathy — urgent)
- Axial neck pain (no radiation)
- Muscle / ligament / facet joint origin
- Related to posture, prolonged sitting, poor ergonomics
- Occupational (VDU / screen work)
- Stress / tension
- Self-limiting in most, recurrent in some
- No neurological deficit
- RA (atlantoaxial instability — serious)
- Psoriatic arthritis
- Axial SpA (AS — cervical involvement late)
- Fever / meningism (meningitis, epidural abscess)
- Night pain / weight loss (malignancy, infection)
- Trauma (cervical fracture — immobilise)
- Torticollis in child (atlanto-axial subluxation — urgent imaging)
- Bilateral arm or leg symptoms
- Shoulder (rotator cuff, AC joint)
- TMJ dysfunction
Numbness in Hands ▼
- Which fingers? (thumb/index/middle = median; little/ring = ulnar)
- Palm vs dorsum
- Nocturnal vs positional vs constant
- Bilateral vs unilateral
- Associated neck pain / radiation from neck (cervical origin)
- Weakness / clumsiness
- Thumb, index, middle, lateral ring (palmar — NOT back of hand)
- Does NOT involve little finger
- Nocturnal symptoms (waking = classic)
- Shake hands to relieve (flick test)
- Thenar wasting (late)
- Tinel's / Phalen's positive
- Risk: pregnancy, hypothyroid, DM, RA, obesity, previous wrist fracture
- Diagnosis: nerve conduction studies
- Little finger and medial ring finger
- Hypothenar wasting, intrinsic weakness (late)
- Worse with elbow flexion (driving, sleeping, phone)
- Cubital tunnel test positive (full elbow flexion 1 min)
- Froment's sign
- Distinguish from Guyon's canal (ulnar at wrist) — same distribution but no forearm involvement
- C6: thumb / index + radial forearm, biceps weakness, biceps reflex reduced
- C7: middle finger + posterior arm, triceps weakness, triceps reflex reduced
- C8: ring / little finger + medial forearm, grip weakness
- Neck pain, worse with extension / Spurling's test
- NB: causes differ from peripheral nerve compression
- Cold / emotional trigger
- Triphasic colour change: WHITE (spasm) → BLUE (deoxygenation) → RED (reperfusion)
- Bilateral, symmetrical, fingers (thumbs less)
- Primary: young women, no systemic disease, benign
- Secondary (Raynaud's phenomenon): systemic sclerosis (skin tightening, dysphagia), SLE, RA, vibration white finger (HAV)
- ANA screen for secondary causes — refer rheumatology
- Thoracic outlet syndrome: whole arm, positional, worse arms raised (cervical rib, Pancoast)
- Peripheral neuropathy: bilateral glove-and-stocking, length-dependent (DM, alcohol, B12)
- Vitamin B12 deficiency: subacute combined degeneration of cord (dorsal + lateral columns)
Numbness in Legs ▼
- Onset (acute = stroke; insidious = neuropathy / radiculopathy)
- Distribution (dermatomal vs stocking vs bilateral)
- Unilateral vs bilateral
- Associated weakness
- Bladder / bowel (cauda equina)
- Walking distance before symptoms (neurogenic claudication)
- Sudden onset, unilateral numbness (face / arm / leg)
- Associated weakness, speech, vision (FAST / BE-FAST)
- No pain
- FAST pathway: same-day referral
- TIA: transient < 24h, ABCD2 score
- L3/4: anterior thigh and medial calf, knee jerk affected
- L5: lateral calf + dorsum foot + big toe, possible foot drop
- S1: lateral foot + sole + little toe, ankle jerk reduced
- Low back pain + dermatomal radiation
- Positive SLR (L4/5/S1)
- Aggravated by coughing / Valsalva
- Bilateral leg pain + heaviness + numbness on walking
- Relieved by bending forward (shopping trolley, sitting, squatting)
- Worsened by standing and walking
- Contrast with vascular claudication (relieved by standing still)
- Age > 60, insidious, progressive
- MRI lumbar spine
- Bilateral stocking distribution (toes first)
- Burning, tingling, or 'dead' quality
- Absent ankle jerks (early)
- Impaired vibration/proprioception
- Causes: DM (most common), alcohol, B12 deficiency, hypothyroid, CKD, medications
- Saddle / perineal anaesthesia
- Bladder retention (painless overflow)
- Bowel dysfunction
- Bilateral leg weakness
- EMERGENCY: MRI same day, surgical decompression
- Young adults, relapsing-remitting
- Lhermitte's sign, Uhthoff's
- Optic neuritis, diplopia, ataxia, bladder
- Urgent neurology
Palpitations ▼
- Character (fast, slow, irregular, flutter, racing, missed beats)
- Onset / offset (sudden vs gradual)
- Paroxysmal vs persistent
- Duration
- Associated symptoms during attack
- Chest pain / breathlessness / dizziness during palpitations
- Syncope (high risk — urgent cardiac review)
- Previous arrhythmia / structural heart disease
- Family history: sudden death, cardiomyopathy, long QT
- ECG (essential in all patients with palpitations)
- Exercise
- Caffeine, alcohol
- Recreational drugs (cocaine, MDMA)
- Stress / anxiety
- Posture (POTS — young women, worse on standing)
- Hyperthyroid symptoms
- Phaeochromocytoma (paroxysmal: headache + sweating + palpitations + pallor + HTN)
- Hypoglycaemia (DM)
- Beta-agonists (salbutamol)
- Levothyroxine overtreatment
- Decongestants / sympathomimetics
- QT-prolonging drugs: antipsychotics, antihistamines, macrolides, TCAs
PR Bleeding / Rectal Bleeding ▼
- Colour (bright red vs dark vs melaena)
- Volume, on paper vs coating vs mixed through stool
- Painful vs painless
- Duration
- Bright red on paper (haemorrhoids, fissure)
- Pain on defecation (fissure)
- Straining / constipation
- Pruritus ani
- Change in bowel habit > 6 weeks (especially > 45)
- Blood mixed through stool / dark blood
- Weight loss
- Tenesmus, mucus
- Family history CRC / Lynch / FAP
- Iron deficiency anaemia
- Bloody diarrhoea + mucus + cramps + urgency
- Extra-intestinal: mouth ulcers, joints, eyes, skin
- Melaena (black, tarry, offensive)
- Haematemesis
- NSAIDs / aspirin / liver disease
- Diverticular (elderly, painless, heavy)
- Angiodysplasia (elderly, recurrent)
- Anticoagulants
Rash / Skin Lesion ▼
- Duration, distribution, character (macular, papular, vesicular, purpuric, urticarial, target lesions)
- Pruritus
- Progression / spread
- Previous similar episodes
- New medication, new food, contact (latex, nickel, plants)
- Sun exposure
- Stress (eczema, psoriasis flare)
- Infection (viral exanthem)
- Fever
- Joint pains
- Airway symptoms (anaphylaxis — emergency)
- Mucous membrane (Stevens-Johnson — emergency)
- Eye symptoms
- Non-blanching purpura (meningococcal — emergency; vasculitis, ITP)
- Butterfly rash (SLE)
- Target lesions (erythema multiforme)
- Dermatomyositis (heliotrope, Gottron's papules)
- Atopic history, family history
- Occupation / hobbies
- Travel history
- Sexual history (secondary syphilis, HIV seroconversion)
Rash on Hands and Feet ▼
- Distribution (palms only / soles only / both — bilateral palmoplantar distinctive)
- Character (vesicular, pustular, papular, purpuric, peeling, keratotic)
- Duration
- Pruritus
- Age of patient (infant / child / adult)
- Fever and systemic features
- Contacts with similar rash
- Intensely itchy deep-seated vesicles on palms, soles, lateral fingers
- Tapioca-like vesicle appearance
- Symmetrical, recurrent episodes
- Triggers: stress, heat, sweating, nickel, fungal infection elsewhere (id reaction)
- Treatment: potent topical steroids, emollients, avoidance of triggers
- Children < 5 (Coxsackie A16, Enterovirus 71)
- Vesicular rash: palms, soles, between toes
- Oral ulcers (gums, tongue, inner cheeks)
- Mild fever, malaise
- Highly contagious — school exclusion until vesicles crusted
- Self-limiting 7–10 days
- ⚠️ Not related to animal foot-and-mouth disease
- Children < 5 (peak 18–24 months)
- PROLONGED FEVER > 5 DAYS + 4 of 5 criteria:
- — Polymorphous rash (any type, often nappy area)
- — Bilateral non-exudative conjunctivitis
- — Oral changes: strawberry tongue, cracked lips, oral erythema
- — Cervical lymphadenopathy (usually unilateral)
- — Extremity changes: erythema/oedema (acute); desquamation of fingertips/toes (subacute)
- Incomplete Kawasaki: fever + 2 criteria + raised CRP/ESR — still consider
- RISK: coronary artery aneurysms — paediatric emergency
- TREATMENT: IVIG + aspirin — URGENT paediatric referral
- Children and young adults (3–15 years)
- Palpable purpura: lower limbs and buttocks (gravity-dependent)
- Arthralgia / arthritis
- Abdominal pain (GI involvement, intussusception risk)
- Haematuria / proteinuria (IgA nephropathy)
- Preceded by URTI
- Monitor BP and urine in all
- Copper-penny papular rash on PALMS AND SOLES (classic bilateral involvement — exam favourite)
- Generalised lymphadenopathy
- Condylomata lata (genital)
- Mucous patches
- Malaise, fever, headache
- 4–8 weeks after primary chancre (often missed)
- Sexual history / HIV testing
- Serology: TPPA + VDRL/RPR
- Erythema multiforme: target lesions on hands / arms (post-HSV/Mycoplasma)
- Palmoplantar psoriasis: hyperkeratotic plaques, may be pustular (PPP)
- Reactive arthritis (Reiter's): keratoderma blennorrhagica on palms/soles + urethritis + conjunctivitis + arthritis
- Contact dermatitis: distribution follows allergen/irritant
Red Eye ▼
- Painful vs painless?
- Visual change vs normal vision?
- Discharge type (watery / mucopurulent / none)?
- Unilateral vs bilateral?
- Contact lens wearer?
- Watery / serous discharge
- Starts unilateral, spreads bilateral
- Foreign body / gritty sensation
- Recent URTI
- Highly contagious
- Self-limiting 7–14 days
- No antibiotic drops routinely needed
- ⚠️ Neonatal discharge = URGENT (chlamydia, gonococcus — sight-threatening)
- Mucopurulent sticky discharge
- Morning sealing / crusting
- Uni or bilateral
- Topical chloramphenicol (self-limiting without treatment too)
- Chlamydial: chronic, follicular, STI history — systemic azithromycin
- Intense itch (hallmark — distinguishes from infective)
- Watery bilateral discharge
- Chemosis (conjunctival oedema)
- Associated rhinitis / atopy
- Seasonal or perennial
- Deep aching pain (NOT surface itch)
- Photophobia (ciliary muscle — blinks in any light)
- Blurred vision
- Perilimbal (ciliary) flush — redness worse around iris
- Small irregular pupil (posterior synechiae)
- Associated: HLA-B27 conditions (AS, IBD, psoriatic, reactive arthritis), sarcoidosis, TB
- URGENT same-day ophthalmology referral
- Severe constant eye pain
- Nausea and vomiting (often misdiagnosed as migraine / GI)
- Halos around lights
- Decreased vision
- Fixed mid-dilated OVAL pupil
- Rock hard eye on palpation
- Precipitants: darkness, mydriatics, anticholinergics
- EMERGENCY: IV acetazolamide, pilocarpine, urgent ophthalmology
- Unilateral sectoral redness
- Dull mild ache (not severe)
- No discharge, minimal photophobia
- Normal vision
- Self-limiting 1–4 weeks
- Associated: IBD, RA, CTD
- Deep boring pain, exquisitely tender to touch
- Purplish / deep red discolouration
- Photophobia, impaired vision in severe cases
- Associated: RA, GPA, SLE, infections
- Risk: scleral thinning / perforation
- Urgent ophthalmology
- Corneal abrasion: FB sensation, photophobia, lacrimation — fluorescein positive
- Herpes simplex keratitis: dendritic ulcer, recurrent — ⚠️ NO STEROID DROPS (will worsen dramatically)
- Infective keratitis: contact lens wearer, severe pain, purulent — URGENT
- Subconjunctival haemorrhage: dramatic, painless, normal vision — check BP if recurrent
Shortness of Breath / Dyspnoea ▼
- Acute vs subacute vs chronic
- At rest vs exertion
- Exercise tolerance (MRC 1–5)
- Orthopnoea, PND
- Wheeze, stridor, cough
- Orthopnoea, PND, ankle swelling
- Palpitations, chest pain
- Previous MI / cardiac history
- Wheeze (asthma, COPD)
- Productive cough (LRTI, COPD, bronchiectasis)
- Haemoptysis
- Fever
- Stridor (upper airway — urgent)
- Pleuritic chest pain (PE, pneumonia)
- Smoking history
- Occupational / pet exposure
- Night sweats / weight loss (TB, malignancy)
- Recent immobility, surgery, pregnancy
- OCP / HRT
- DVT features (leg)
- Previous DVT / PE
- Pallor, fatigue, dietary history (anaemia)
- Anxiety / panic
- Tingling (hyperventilation)
- Recent stressor
- Beta blockers (asthma bronchospasm)
- NSAIDs (AERD)
- Anaphylaxis (emergency)
Shoulder Pain ▼
- Location (anterior, lateral, posterior, tip/AC)
- Onset (acute vs insidious)
- Radiation (arm/hand = nerve root; neck = cervicogenic)
- Which movements affected
- Night pain (frozen shoulder, cuff tear, malignancy)
- Age (young athlete vs middle-aged vs elderly)
- Dominant side, occupation, sport
- Painful arc: 60–120° abduction (supraspinatus)
- Weakness of abduction / external rotation
- Hawkins-Kennedy test (impingement)
- Empty can / drop arm (full thickness tear)
- Age > 40, overhead activities
- Global restriction ALL movements (active AND passive)
- External rotation reduced first and most
- Three stages: freezing (pain++) → frozen (stiffness max) → thawing (recovery)
- Duration 18 months to 3 years typically
- Night pain severe (freezing phase)
- Associated: diabetes (3× higher risk), hypothyroid, Parkinson's, post-MI
- Patient often unable to put on jacket / wash hair
- Pain at tip of shoulder (AC joint)
- Point tenderness over AC joint
- Cross-body adduction test positive
- AC joint OA (weight lifters, older)
- AC joint separation: direct trauma / fall, step deformity
- Age > 50 (almost never < 50)
- BILATERAL shoulder AND hip girdle aching
- Morning stiffness > 45 minutes
- Cannot raise arms above head
- Cannot get off chair / toilet without help
- NO muscle weakness
- ESR > 40, CRP elevated
- Dramatic response to prednisolone 15mg within 48–72h (diagnostic)
- Exclude: GCA (visual / jaw symptoms), malignancy, late-onset RA
- C4/5: shoulder tip / deltoid area
- C5/6: shoulder + lateral arm + thumb/index
- Reduced cervical movement, Spurling's test
- Glenohumeral OA: global stiffness + pain
- Long head of biceps rupture: 'Popeye' sign, snap, weak supination
- Calcific tendinopathy: acute severe pain, calcium on X-ray
- Pancoast tumour: apex lung, Horner's, C8/T1 distribution (shoulder + arm)
- Diaphragmatic irritation: right shoulder tip (hepatic, post-laparoscopy)
Sore Throat ▼
- Duration, severity
- Exudate / pus
- Trismus (difficulty opening mouth — quinsy)
- Drooling
- Stridor (epiglottitis — do not examine throat — emergency)
- Dysphagia / odynophagia
- Hoarseness / muffled ('hot potato') voice
- Cervical lymphadenopathy (anterior vs posterior)
- Unilateral peritonsillar swelling (quinsy — uvular deviation)
- Ear pain (referred otalgia)
- Fever
- Fatigue (glandular fever — EBV)
- Splenomegaly (LUQ pain — avoid contact sports if EBV — splenic rupture risk)
- Maculopapular rash after amoxicillin (EBV — never prescribe penicillin blind)
- Fever > 38°C
- Purulent exudate
- Absence of cough
- Severely inflamed / swollen tonsils
- Anterior cervical lymphadenopathy
- FeverPAIN: onset ≤ 3 days, attendance ≤ 3 days, severely inflamed, purulent, prior antibiotics
- Mouth ulcers (herpangina — Coxsackie)
- Rash: strawberry tongue + sandpaper rash = scarlet fever — treat
- Recurrent tonsillitis (Paradise criteria for tonsillectomy)
- Oral candidiasis (immunosuppressed)
Sweating (Profuse) ▼
- Generalised vs focal (focal = primary hyperhidrosis)
- Nocturnal (wetting clothes/sheets) vs daytime vs both
- Episodic vs continuous
- Triggers
- Associated flushing / palpitations / weight loss
- Menopause / perimenopause: most common in women > 45, hot flushes, night sweats, irregular periods
- Hyperthyroidism: heat intolerance, weight loss, palpitations, diarrhoea
- Phaeochromocytoma: PAROXYSMAL (headache + palpitations + sweating + pallor + HTN = 5 Ps), precipitated by stress / tyramine / surgery
- Carcinoid syndrome: flushing (facial) + diarrhoea + wheeze + right-sided valve lesions
- Acromegaly: enlarging hands/feet, macroglossia, sweating + headache
- Lymphoma (Hodgkin's / NHL): drenching night sweats, weight loss, lymphadenopathy (B symptoms)
- Leukaemia: night sweats, infections, fatigue
- Solid tumour (paraneoplastic)
- Weight loss + drenching night sweats = investigate for malignancy
- TB: classic drenching night sweats + cough + haemoptysis + weight loss + contacts
- Endocarditis: fever, night sweats, embolic phenomena, murmur
- Brucellosis: animal contact, undulating fever
- HIV / AIDS: constitutional symptoms
- SSRIs / SNRIs (very common clinical cause)
- Opioids (also withdrawal sweating)
- Tamoxifen / aromatase inhibitors
- Steroids
- Levodopa
- Alcohol withdrawal (profuse diaphoresis + tremor + agitation)
- Focal, bilateral symmetric: axillae, palms, soles, groin, face
- Onset childhood / adolescence
- NO night sweats (distinguishes from secondary)
- Family history positive
- Normal TFTs / no systemic cause
- Significant social and occupational impact
- Treatment: aluminium chloride (topical), iontophoresis, Botox injections, anticholinergics
Syncope / Blackout ▼
- Warning before LOC
- Duration of LOC
- Recovery time
- Tongue biting (lateral = seizure)
- Incontinence
- Witnessed account essential
- Preceding activity
- Prodrome: nausea, sweating, greying vision
- Triggers: prolonged standing, heat, pain, needles, emotion
- Rapid complete recovery
- Pale / sweaty
- Sudden without warning (arrhythmia)
- During exertion (HOCM, aortic stenosis)
- Chest pain / palpitations before
- Family history sudden cardiac death
- Lying or seated syncope
- ECG abnormalities
- On standing
- Medication (antihypertensives, diuretics, alpha blockers)
- Autonomic neuropathy
- Lateral tongue biting (seizure)
- Post-ictal > 5 min confusion (seizure)
- Tonic-clonic > 30 seconds (seizure)
- Brief jerks in syncope = normal (don't confirm seizure)
- Aura (seizure)
- Cyanosis (seizure or cardiac)
- Hypoglycaemia (DM)
- Carotid sinus hypersensitivity (elderly, collar turning)
- Alcohol / recreational drugs
Tooth Pain ▼
- Location (upper / lower / quadrant)
- Character (sharp electric vs throbbing vs dull)
- Triggers (cold, sweet, hot, biting)
- Swelling (gum / face)
- Fever / systemically unwell
- Previous dental treatment
- Dental caries: sharp pain triggered by cold / sweet, brief
- Reversible pulpitis: lingering sensitivity, no spontaneous pain
- Irreversible pulpitis: spontaneous severe throbbing, woken at night, hot makes worse
- Periapical abscess: constant throbbing, tender on tapping, facial swelling, fever
- Periodontal disease: gum-related, bleeding, mobile tooth
- Cracked tooth: sharp pain on biting and releasing
- Dry socket: post-extraction > 24h, severe, no clot
- Jaw pain / ache, clicking / crepitus
- Restricted mouth opening
- Referred to ear / temple / neck
- Bruxism (morning temporal / masseter pain, worn facets)
- Stress / anxiety link
- Maxillary sinusitis: upper posterior teeth, nasal congestion, facial pressure
- Trigeminal neuralgia: electric shock / stabbing, seconds, trigger zones, refractory periods
- Cardiac angina: rarely jaw / lower tooth pain — consider in risk factor patients with exertional component
- Ludwig's angina: bilateral submandibular space infection, floor of mouth swelling, airway risk — EMERGENCY
- Pericoronitis: partially erupted wisdom tooth, trismus, severe pain
- Facial cellulitis from dental abscess: refer same day
Urinary Incontinence ▼
- Type (stress, urge, mixed, overflow, functional)
- Duration, severity (pads/day)
- Impact on quality of life
- Precipitating factors
- Leakage on cough, sneeze, laugh, exercise
- No preceding urgency
- Obstetric history (parity, mode, birth weight, forceps)
- Previous pelvic surgery
- BMI, prolapse symptoms
- Sudden strong urge, unable to delay
- Frequency, nocturia
- Triggers: cold, running water, key in lock
- Constant dribbling / small amounts
- Poor flow / hesitancy
- Obstructive (prostate in men)
- Neurological (diabetic autonomic neuropathy)
- Mobility / cognitive impairment
- UTI (new onset in elderly woman — always MSU)
- Medications: diuretics, alpha blockers, anticholinergics
- Diabetes (polyuria)
- Constipation (urge symptoms)
UTIs — Recurrent ▼
- Women: ≥ 2 UTIs in 6 months OR ≥ 3 in 12 months
- Men: ANY UTI = investigation (unusual — exclude structural cause)
- Always confirm with MSU culture
- Exclude bladder overactivity / interstitial cystitis
- Sexual intercourse (E. coli from bowel / perineum)
- Spermicide use
- Atrophic vaginitis (postmenopausal — oestrogen deficiency)
- Incomplete bladder emptying
- Constipation (elderly)
- Diabetes (glycosuria)
- Immunosuppression
- Pelvic organ prolapse
- Post-coital prophylaxis: single dose nitrofurantoin / trimethoprim
- Daily low-dose prophylaxis: nitrofurantoin 50mg or trimethoprim 100mg nocte
- Topical oestrogen (postmenopausal): significant reduction in recurrence
- D-mannose supplements (some evidence)
- Void after intercourse
- Adequate hydration, avoid spermicides
- Any culture-confirmed UTI warrants investigation
- Exclude: BPH (LUTS, incomplete emptying)
- Prostate cancer (PSA, DRE)
- Urethral stricture (reduced flow, hesitancy)
- Renal calculi (nidus for infection)
- STI / urethritis (urethral discharge, NAAT swab)
- MSM (rectal flora)
- Refer urology after first confirmed UTI in a man
- Same organism recurring: CTKUB (CT urinary tract)
- Haematuria + recurrent UTI: cystoscopy
- Optimise diabetes control
- Struvite stones: Proteus / Klebsiella (urease-producing) — suspect renal calculus
Vaginal Bleeding — Abnormal ▼
- Duration, amount, timing (IMB, PCB, postmenopausal)
- Associated pain
- LMP (always)
- IMB / PCB (cervical ectropion, cervicitis, CIN, cervical cancer)
- Contraception (IUD, OCP, implant — consider)
- Pregnancy risk (ectopic — shoulder tip pain, haemodynamic instability)
- Recent STI screen
- Duration since menopause (> 12 months)
- HRT type / duration
- Tamoxifen (5× endometrial cancer risk)
- BMI / diabetes / hypertension (endometrial cancer risk)
- Cervical smear history
- Atrophic vaginitis (most common cause — diagnosis of exclusion)
- Pelvic pain / deep dyspareunia (endometriosis, PID)
- Previous STIs / cervical treatment
- Anticoagulants
- Von Willebrand disease
- Thyroid disease
Vaginal Discharge ▼
- Duration, amount, colour, consistency
- Odour (fishy = BV; yeasty = thrush)
- Pruritus / irritation
- Blood-stained
- Dysuria, pelvic pain / deep dyspareunia (PID)
- Post-coital bleeding
- New / multiple partners, unprotected sex
- STI contacts
- Previous STIs
- Recent antibiotics (candidiasis)
- Contraception (IUD)
- Recent cervical procedure / smear
- Pregnancy
- Postmenopausal (atrophic vaginitis)
- Immunosuppression (recurrent candidiasis)
- Diabetes (recurrent candidiasis — check HbA1c)
Vision Changes ▼
- Sudden vs gradual
- Unilateral vs bilateral
- Type (loss, blur, distortion, floaters, flashes, field defect, diplopia, halos)
- Painful vs painless
- Transient vs persistent
- Acute angle closure glaucoma: severe pain, red eye, halos, fixed mid-dilated pupil, nausea — EMERGENCY
- Anterior uveitis: photophobia, deep ache, ciliary flush, small pupil
- Scleritis: deep boring pain, exquisite tenderness
- Corneal ulcer: contact lens wearer, severe pain, photophobia
- Retinal detachment: curtain/shadow, preceded by floaters/flashes — SAME DAY
- CRAO: sudden complete painless loss, cherry red spot — EMERGENCY (< 90 min)
- CRVO: 'stormy sunset' fundus, widespread haemorrhages
- Vitreous haemorrhage: sudden floaters / cobwebs (DM, trauma, PVD)
- Amaurosis fugax: transient monocular loss (TIA) — SAME DAY
- AMD: central loss, distortion (Amsler grid)
- Glaucoma: peripheral loss, insidious
- Diabetic retinopathy (annual screening)
- Cataract: glare, faded colours
- Hypertensive retinopathy
- Optic neuritis: painful, unilateral, colour desaturation — MS
- Diplopia: CN III (down and out, ptosis, dilated pupil = surgical emergency), CN VI (fails to abduct), CN IV (vertical)
- Homonymous hemianopia (stroke, tumour)
- Migraine aura: zigzag, 15–30 min then headache
- Sudden painless loss / amaurosis fugax
- Temporal tenderness, jaw claudication
- STEROIDS SAME DAY (before biopsy if visual symptoms)
- Diabetes (retinopathy screening)
- Hypertension
- MS history
- Contact lens wear
Weight Loss — Unintentional ▼
- Amount and timeframe (clinically significant = > 5% in 6–12 months)
- Intentional vs unintentional
- Appetite: increased (hyperthyroid, DM, malabsorption) vs decreased (malignancy, depression)
- Night sweats, lymphadenopathy
- Localising: haemoptysis, haematuria, bowel change, dysphagia, bone pain
- Abdominal mass
- Fatigue
- Hyperthyroidism: heat intolerance, palpitations, diarrhoea, tremor
- DM: polyuria, polydipsia, fatigue (type 1 / LADA)
- Addison's: pigmentation, postural dizziness, salt craving
- Diarrhoea / steatorrhoea, abdominal pain
- Dysphagia, bowel habit change
- Coeliac features
- Depression (reduced appetite)
- Anxiety
- Eating disorder
- Dementia (forgetting to eat)
- HIV, TB, chronic infection
- Night sweats, fever, travel history
- Social isolation, financial difficulty
- Difficulty cooking
- Alcohol / drug use
- Dentition problems
Great history-taking is not about exhaustively interrogating every organ system from head to toe. It is about asking the right questions — the ones that logically flow from the presenting symptom, help you narrow your differential, and ensure that serious pathology is not missed. This skill separates the competent clinician from the truly excellent one.
Symptom-specific assessment means starting with a patient's complaint and systematically asking targeted questions related to the clinical systems most likely to explain that symptom. A patient with chest pain needs questions drawn from cardiac, respiratory, gastrointestinal, musculoskeletal, and psychiatric systems — not a generic head-to-toe review.
This approach results in more focused consultations, a richer differential diagnosis, and — most importantly — safer clinical practice.
Who This Is For
- GP trainees (ST1–ST3)
- Foundation doctors in GP posts
- Nurse practitioners & ANPs
- Physician associates & medical students
- Any clinician with undifferentiated presentations
How to Use This Page
Search for any presenting symptom using the search bar, or browse the A–Z list. Inside each accordion, questions are grouped by clinical system. Use as a quick reference before surgery, for OSCE preparation, or as a framework for teaching.
Level: Medical School Essentials
This is the minimum expected knowledge base — the core framework taught at undergraduate level. It is not exhaustive: clinical context, patient story, and professional judgement will always guide what additional questions are needed.
The Golden Rule
For every symptom, always ask yourself: "Have I excluded the dangerous diagnoses?" Serious and life-threatening conditions are listed prominently within each accordion for exactly this reason.
Before symptom-specific questions, every history needs a solid structural backbone.
SOCRATES — Characterising Any Symptom
ICE — The Psychosocial Dimension
No history is complete without understanding the patient's inner world. ICE is fundamental to patient-centred consulting.
Background Safety Net — Always Explore
Certain features demand urgent action regardless of the presenting symptom. These cross-cutting red flags must be actively sought in every consultation.
⛔ Always exclude these features across all presentations
The following guide summarises the clinical feature combinations that should trigger urgent or emergency action. It complements the individual symptom accordions — use it as a rapid safety checklist when something doesn't feel right.
- Thunderclap headache (worst ever — SAH until proven otherwise)
- Curtain / shadow across visual field (retinal detachment)
- CRAO: sudden complete painless monocular loss + cherry red spot
- Acute angle closure glaucoma: severe pain + fixed mid-dilated pupil + nausea + halos
- STEMI: ST elevation + crushing chest pain + diaphoresis
- Aortic dissection: tearing chest/back pain + BP differential
- Ruptured AAA: acute severe abdominal/back pain + pulsatile mass + collapse
- Cauda equina: saddle anaesthesia + urinary retention + bilateral leg weakness
- Non-blanching purpuric rash + fever (meningococcal septicaemia)
- Ludwig's angina: bilateral submandibular swelling + trismus + floor of mouth
- Anaphylaxis: stridor + urticaria + hypotension after trigger
- Stroke (FAST positive): face / arm / leg / speech — onset < 4.5h (thrombolysis)
- CN III palsy with DILATED PUPIL (posterior communicating artery aneurysm)
- Septic arthritis: hot swollen joint + fever + systemically unwell
- Acute limb ischaemia: 6 Ps (pain, pallor, pulseless, paraesthesia, paralysis, perishing cold)
- Amaurosis fugax (transient monocular loss) — TIA of the eye, carotid/cardiac source
- Sudden sensorineural hearing loss — ENT same day (steroid window 24–72h)
- Anterior uveitis: deep ache + photophobia + ciliary flush + miosis
- Temporal arteritis: jaw claudication / visual symptoms + age > 50 → START STEROIDS, don't wait for biopsy
- GCA with visual loss: IV methylprednisolone + same-day ophthalmology
- Suspected cauda equina: saddle area numbness, even without full syndrome
- Obstetric cholestasis: pruritus in pregnancy + raised bile acids
- Kawasaki disease: fever > 5 days in child + any 2–3 criteria — paediatric referral
- Exertional syncope: cardiac cause until excluded (ECG, echo)
- Syncope without warning (lying or seated) — cardiac arrhythmia risk
- Acute angle closure features (incomplete) — ophthalmology same day
- Acute suicidal ideation with plan, intent, means — immediate psychiatric review
- Mastoiditis: postauricular swelling + proptosed pinna + fever + otalgia
- Neonatal eye discharge: any age < 28 days — neonatal ophthalmia protocol
- Suspected meningitis (without rash): neck stiffness + photophobia + fever
- Unexplained hoarseness > 3 weeks, age > 45 — 2ww laryngoscopy
- Postmenopausal bleeding — 2ww gynaecology (endometrial cancer)
- Painless visible haematuria (any age) — 2ww urology
- Progressive dysphagia — 2ww upper GI
- Epigastric mass ± weight loss — 2ww upper GI
- Rectal bleeding > 45 + change in bowel habit > 6 weeks — 2ww lower GI
- Unexplained iron deficiency anaemia > 50 — 2ww lower GI
- Unilateral nasal polyp (older patient) — 2ww ENT (sinonasal malignancy)
- Left supraclavicular lymphadenopathy (Virchow's) — 2ww (abdominal malignancy)
- Breast lump, any age — 2ww breast
- Jaw claudication / scalp tenderness (GCA) — urgent ESR/CRP, steroids if positive
- Any UTI in a man — urology referral for investigation
- SUFE (adolescent hip): urgent orthopaedic (frog-leg X-ray)
- Rapidly growing or painless neck lump > 3 weeks — 2ww head and neck
- Unexplained weight loss + localising symptom — targeted 2ww pathway
- New floaters + flashes (no field loss yet) — ophthalmology urgently this week (retinal tear risk)
- Sudden SNHL without same-day presentation — escalate if missed window
- PMR confirmed — start prednisolone, baseline BP/glucose/bone protection
- Unexplained progressive back pain > 50 — imaging + bloods (myeloma screen)
- Recurring syncope with incomplete investigation — 24h ECG / loop recorder
- Recurrent UTIs in a woman — prophylaxis strategy + MSU at each episode
- New foot drop — urgent MRI spine / neurology (reversible if early)
- Suspected MND: mixed UMN + LMN + no sensory loss — urgent neurology
- Avascular necrosis risk (steroids + hip pain) — MRI hip (X-ray normal early)
- Sudden unexplained hair loss + systemic features — thyroid, ferritin, FBC, LFTs
- Worsening cognitive decline (new) — full dementia workup + medication review
- Safeguarding concerns identified during any consultation — same day action
- Medication found to be contributing to serious symptom — review and document
- Antenatal pruritus (any trimester) — bile acids + LFTs, even if mild
- Kawasaki disease (incomplete criteria) — do not discharge without paediatric review
Distilled from experienced GP educators, RCGP examiner feedback, training scheme guidance, and the accumulated wisdom of trainees who have been through the process. These are the things that make a real difference — and that nobody puts in the textbook.
The 6:6 Rule — The Most Important Thing in the SCA
The single most common reason trainees underperform in the SCA is poor time management — specifically, spending 9–10 minutes taking history and leaving only 2–3 minutes for management. The result is a rushed, incomplete management discussion that costs marks in the highest-weighted domain.
The fix is simple in principle: aim to transition from data gathering to management at the 6-minute mark. This gives roughly equal time for both, and the Relating to Others domain runs throughout the whole consultation — it doesn't need its own time block.
ICE: Ask It, Use It, Don't Abandon It
One of the most consistently flagged examiner feedback statements is: "Did not return to the patient's ideas, concerns and expectations when forming the management plan." Trainees ask about ICE in the first half of the consultation — and then proceed to ignore it entirely when discussing management.
ICE is not a box to tick in the opening phase. It is the thread that should run through the entire consultation. The management plan should explicitly link back to what the patient told you they were worried about or hoping for.
Say Your Diagnosis Out Loud — Every Time
Examiners can only mark what they can hear. Many trainees reach an accurate working diagnosis in their head — and then manage the patient without ever saying what they think is going on. The examiner cannot award marks for reasoning they never witnessed.
It is equally important to say your diagnosis when you are uncertain. GPs make decisions based on probability when not all the facts are known. Saying "I'm not sure" without offering a working diagnosis or plan is not acceptable — but offering your best working diagnosis with honest uncertainty acknowledged is not just acceptable, it is exactly what good GP consulting looks like.
Specific Safety-Netting Always Beats Generic Safety-Netting
"Come back if things get worse" is weak safety-netting, and examiners know it. It costs marks. Effective safety-netting means telling the patient:
- Exactly which symptoms to watch for
- How quickly to act if they occur (call 999, go to A&E today, come back this week)
- What will happen if they follow the plan and things don't improve within a defined timeframe
Use the Patient Record — It's Right There
A commonly flagged SCA feedback statement is: "Did not make use of information available in the patient's notes." In real GP practice — and in the SCA — the patient record is not background noise. It is clinical data. Referencing it actively demonstrates GP-level thinking:
- "I see you saw my colleague last week about this — how have things been since then?"
- "Our records show you're on metformin and ramipril — is that still correct?"
- "I notice your smear is overdue — is that something we can sort out while you're here?"
Angry Patients: Acknowledge First, Investigate Second
The mistake most trainees make with an angry or distressed patient is either becoming defensive or immediately trying to fix the problem. Both skip the most important first step: acknowledging the emotion.
Once you have genuinely acknowledged how the patient feels — not just as a ritual phrase but as a real response — the consultation follows the same structure as any other. Take the history, form a plan, negotiate an approach. The anger cases specifically test whether you can de-escalate before moving into clinical territory. Many trainees skip straight to defensiveness or explanation, and lose the entire consultation in the first 90 seconds.
Video Your Consultations — It's Uncomfortable and Invaluable
Almost every experienced GP trainer says the same thing: video review is the most powerful learning tool available to GP trainees. And almost every GP trainee avoids it. The discomfort is the point — you cannot see your own blind spots without watching yourself.
Watch specifically for: how long you spend on history before transitioning; whether you actually listen to the patient's response or immediately ask the next question on your mental list; whether your ICE integration is genuine or formulaic; and whether your safety-netting is specific or generic.
The Three Conditions Most Often Missed — And Why
NHS Resolution data from GP medicolegal claims consistently identifies the same three conditions as the most commonly missed in general practice, leading to delayed referral and patient harm. They are not rare — they are under-questioned.
- Cauda equina syndrome: Missed because GPs don't ask explicitly about saddle anaesthesia and urinary retention. The patient doesn't always volunteer it — you have to ask directly. "Have you noticed any numbness or tingling around your bottom or inner thighs? Any problems starting to pass urine?"
- Colorectal cancer: Missed because a 6-week change in bowel habit is not followed up systematically. A single "no" to "any bowel problems?" is not sufficient.
- Subarachnoid haemorrhage: Missed because the thunderclap history is not taken carefully enough. "The worst headache of your life?" doesn't always capture it. Ask: "Did it come on suddenly — within seconds? Was it unlike any headache you've had before?"
Disorganised History-Taking Is a Clinical Safety Issue
RCGP SCA examiner feedback frequently flags "disjointed or scattergun questioning" as a distinct fail marker — not just because it scores poorly, but because it signals a doctor who may miss important clinical issues through lack of system.
Symptom-specific history-taking solves this exactly: by knowing in advance which clinical systems are relevant to a given presenting symptom, you can structure your questions systematically rather than asking whatever comes to mind. This is what this entire page is designed to teach.
In Telephone and Remote Consultations: Don't Cut Red Flag Questions
GP trainees consistently report feeling tempted to omit red flag questions during telephone or video consultations — particularly when they've already decided to bring the patient in. The reasoning is: "I'm going to see them anyway." This reasoning is wrong, and experienced examiners flag it directly.
The red flag questions inform the urgency of your next step. A patient coming in tomorrow afternoon for back pain becomes a patient going to A&E tonight if they disclose saddle anaesthesia. The decision to bring someone in does not replace the clinical history — it is made on the basis of it.
"The Patient Will Tell You the Answer If You Listen"
This comes from a GP and RCGP council representative with years of clinical experience. It sounds deceptively simple. But in practice, trainees often spend the consultation asking questions rather than actually hearing the answers — especially when anxious about time.
Genuine listening — including attention to what the patient does NOT say, how they say things, the hesitations, the non-verbal cues — is not a soft skill. In general practice, it is often the most diagnostically powerful thing you can do. The history is richer than any blood test for most presentations.
Hospital Habits That Kill GP Consultations
Many trainees arrive in GP having spent years in hospital posts where certain consulting habits are appropriate and valued. In UK GP — and especially in the SCA — these same habits are mark-losers:
- Directive decision-making ("you need X") → Replace with shared decision-making ("we've got a couple of options — what would suit you best?")
- Ignoring psychosocial context → In GP, asking about work, relationships, home life is not prying — it is essential clinical data
- Treating empathy as an opener → It should run throughout the whole 12 minutes, not just at the start
- Premature referral → GP manages most things in primary care. "I'll refer you" is often wrong in the SCA; it signals you can't manage the problem yourself
- Extensive clerking → A comprehensive 30-question history is not GP consulting. Focus on what this specific patient with this specific symptom actually needs you to ask
🩺 Symptom-Specific Insider Insights
These are the things experienced clinicians wish someone had told them earlier — the practical, specific pearls that turn knowledge into real consulting ability.
When a patient mentions "some tingling in the legs" while describing back pain — stop and go deeper. Don't move on. Explicitly ask about saddle area sensation, bladder, and bowel before anything else. Many cauda equina claims involve a trainee who noticed neurological symptoms but didn't follow up. The medicolegal standard is clear: if you hear it, you must pursue it.
"Worst headache of your life" is a phrase many patients don't recognise or apply to their own experience. A better approach: "Did it come on in seconds — like being hit over the head?" and "Was it different in character from any headache you've had before?" These questions are more likely to elicit the thunderclap quality that SAH produces.
Trainees consistently overdiagnose BPPV and underdiagnose vestibular migraine. If you do the Dix-Hallpike twice and the vertigo doesn't fatigue, it's almost certainly not BPPV. The two questions that separate BPPV from everything else: "Does it last seconds or minutes?" and "Does the same head movement always trigger it?" If the answers are "minutes" or "not always" — think again.
Hip pain that radiates to the knee is true hip joint pathology until proven otherwise — this is one of the most commonly missed examination findings in GP. Trainees often treat knee pain as a knee problem when the true source is the hip. Examine the hip in every presentation of knee pain in a child or older adult. Perthes and SUFE in children are missed for exactly this reason.
The most common error in shoulder pain assessment is missing PMR. If a patient over 50 presents with bilateral shoulder aching, morning stiffness lasting more than 45 minutes, and difficulty raising their arms — the diagnosis is PMR until proven otherwise. A lot of trainees send these patients to physiotherapy for a long time before someone checks an ESR. It's a tragedy that is easily avoided.
With any twisting knee injury, the timing of swelling is the most informative single question. Immediate swelling within 2 hours means blood in the joint — haemarthrosis — which means internal derangement in around half of cases. Delayed swelling at 12–24 hours means a reactive effusion, pointing toward meniscal injury or less severe structural damage. This question takes 5 seconds and changes the entire clinical pathway.
The distribution of numbness completely determines the diagnosis — but many trainees ask "which fingers are affected?" and settle for "all of them." Push further: "Is it the little finger as well?" — if yes, it's almost certainly ulnar nerve territory, not carpal tunnel. The little finger is the single most clinically useful question in peripheral nerve assessment of the hand.
The single most important question in syncope is: "Did you have any warning beforehand?" Vasovagal syncope has a prodrome — warmth, nausea, tunnel vision — before collapse. Cardiac arrhythmia has none. A sudden collapse with no warning in a patient without a vasovagal trigger needs an ECG before they go home. Exertional syncope in particular needs same-day cardiac assessment regardless of how well the patient looks in your consulting room.
The question that separates the dangerous from the benign: "Does it itch?" Itching almost always means allergic conjunctivitis — a benign self-limiting condition. A painful red eye without itching, with photophobia, visual change, or a fixed pupil, needs urgent referral. Many trainees prescribe antibiotic drops to red eyes that need ophthalmology that day.
Pruritus without a visible rash in a pregnant woman is obstetric cholestasis until proven otherwise. Many trainees reassure a patient about "normal pregnancy stretching." The correct response is bile acids and LFTs, even if the itch seems mild. The stakes — fetal arrhythmia and stillbirth — are too high for watchful waiting without investigation.
Hoarseness lasting more than 3 weeks in a patient over 45 is a 2-week-wait referral. Full stop. Many trainees try a course of voice rest or assume reflux and follow up in a few weeks. This is a well-documented pathway to delayed laryngeal cancer diagnosis. The threshold is set deliberately low because early laryngeal cancer is highly curable.
When applying the Ottawa Ankle Rules, many trainees examine the wrong part of the malleolus. The rule requires tenderness at the posterior 6cm or the tip — not at the anterior. Tenderness at the anterior lateral malleolus is almost universal in any ankle sprain (ATFL tear) and does not trigger the rule. Get the anatomy right before you confidently tell a patient they don't need an X-ray.